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As semaglutide delays digestion, large meals can take longer to be digested, which worsens acid reflux

Dialysis dependence or an estimated glomerular filtration rate below 30 mL min1 1.73 m2 represents an absolute contraindication unless the infusion is placed immediately before dialysis under nephrology supervision

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A landmark physiology paper published in Obesity Reviews modeled the mathematics precisely

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This delayed gastric emptying can lead to food remaining in the digestive system for extended periods, particularly foods high in sulphur-containing compounds such as proteins