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Early evidence already suggests that such multiplex regimens outperform single-agent therapy where metabolic heterogeneity blunts isolated responses (81, 85) (Table 3) Future work must dissect mechanism-specific dosing ratios, develop quantitative biomarkers of combinatorial efficacy, and deliver large, stratified, randomized trials to confirm both safety and clinical relevance

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The enzymatic activities of -glutamylcysteine synthetase and gluthione synthetase were determined using the method described previously with a slight modification 43

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Riboflavin deficiency occurs commonly in low- and middle-income countries