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Preclinical studies suggest that NNMT inhibition can mitigate diet-induced weight gain and improve metabolic health without altering food intake

GLP-1 121 Q

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Here, both Arg123 and Arg127 of semaglutides backbone (cyan cartoon, Figures 3, 4 and 5) formed interfacial salt bridges with Glu40 of GLP-1R ECD (green cartoon, Figures 3, 4 and 5), the details of which are included in Table 4 and shown in Figure 5

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Archived from the original on October 14, 2018