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Two Phase 3 clinical trials, RECONNECT 1 and RECONNECT 2, enrolled more than 1,200 premenopausal women and demonstrated its effectiveness
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Treatment of rats with roridin E caused minimal toxicity on the hepatic and renal tissue, however, co administration of linoleic acid with roridin E resulted in increase toxicity due to increased incorporation to the cell membrane or inhibit its biotransformation [159]
People who are pregnant are usually not included in clinical drug trials
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