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In the first case, hepatic steatosis presents without indication of inflammation, while in NASH hepatic steatosis is connected to lobular inflammation and apoptosis that may lead to fibrosis and cirrhosis [1] (Figure 1)

Biomolecules , 10 (2), 320

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Unlike native -MSH, which has a very short plasma half-life due to rapid enzymatic degradation, MT-1 incorporates a linear sequence modification that significantly extends its stability in biological matrices while preserving high-affinity binding at melanocortin receptors primarily MC1R, the receptor responsible for eumelanin synthesis in melanocytes