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Notably, bi-allelic MC4R mutation carriers had long-term outcomes as poor as those with bi-allelic LEPR or POMC mutations, suggesting that biallelic mutations in LMP genes generally lead to more severe impairment of surgical efficacy compared to heterozygous mutations

In short, researchers are strongly encouraged to become familiar with relevant findings on the best handling and administration protocols for specific uses of BPC-157, as optimal delivery methods are subject to change

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