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Access through compounded semaglutide has narrowed compared to 20232024

In fact, liraglutide (1.8 mg daily) and semaglutide (0.5 mg weekly) both significantly outperformed dulaglutide (1.5 mg weekly) for weight loss in head-to-head trials at doses that induce comparable HbA1c lowering (13, 22)

3.5 Semaglutide intervention and fecal microbiota transplantation improved the dysbiosis of gut microbiota in obese mice, increasing the relative abundance of beneficial bacteria, and affecting the levels of short-chain fatty acids The species accumulation curve and dilution curve indicated that the sample size and sequencing depth were sufficient (Supplementary Figure S3A)

The dose is also available through GoodRx for $399 per month

National Institute of Diabetes and Digestive and Kidney Diseases describes GLP-1 agonists as one of the most effective medical tools currently available for sustained weight loss, with average reductions of 15% or more of body weight in the key registration trial, per the STEP 1 trial published in the New England Journal of Medicine in 2021