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Previous AngIV analogs, while showing promise in animal models of dementia, were hindered by poor metabolic stability indicated by a short half-life, and an inability to cross the BBB due to their peptide nature

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Subcutaneous injection distributes the peptide systemically, meaning it can affect skin throughout the body rather than only where directly applied

That distinction matters because it separates AOD 9604 from full growth hormone, which carries different risks

This article explores B12 in more detail and the research surrounding its connection with diabetes

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