Best liver supplements at a glance Best overall: mindbodygreen liver detox+ Best for liver enzymes: Dose for your liver Best for berberine: Thorne Liver Cleanse Best greens powder: AG1 Next Gen Best for digestion: Cymbiotika Liver Health+ Best of milk thistle: Gaia Herbs Milk Thistle Best program: Metagenics Clear Change 10-Day Detox Program liver detox+ by mindbodygreen Dose 2 capsules Third party tested Yes Dietary considerations Vegan, gluten-free, dairy-free, soy-free, and GMO-free Pros & Cons Pros & Cons Pros Supports the detoxification processes of the liver, kidneys, lungs, gut, & skin* Combats oxidative stress and promotes binding, filtering, & removal of toxins* Provides Setria glutathione, NAC, milk thistle, vitamin Cons Capsule format may not appeal to those who prefer powders or liquids We gave mindbodygreens liver detox+ the best overall spot because it delivers comprehensive, targeted support for liver health in a thoughtfully formulated blend of nutrients and bioactives.* The formula provides 5 key antioxidants, including clinically studied compounds like milk thistle, N-acetyl-L-cysteine (NAC), choline, selenium, and vitamin C.* Together, these ingredients support the livers natural detoxification pathways, antioxidant defenses, and healthy cellular function.* What makes it unique

The full safety picture, including who should skip it, is in our guide to L-arginine side effects and safety
Research suggests it may increase endogenous GLP-1 secretion from intestinal L-cells, providing a mild GLP-1 boosting effect that complements rather than replaces exogenous GLP-1 therapy
doi:10.1056/NEJMoa2032183Wilding JPH, Batterham RL, Davies M, et al
Chronic exercise improves hepatic acylcarnitine handling
National Institute on Alcohol Abuse and Alcoholism (NIAAA)