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Moreover, in agreement with the critical role of the capsule for meningococcal intracellular survival (Spinosa et al., 2007), siaD deletion in the MC58 strain led to an increase in adhesion to Calu3 LLI but to a strong reduction in intracellular bacteria and in transcellular crossing (Sutherland et al., 2010)
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Later MRI studies confirmed this, documenting sharp VAT reductions within just 12 weeks of treatment
It binds copper ions, helping activate enzymes that build collagen and elastin fibers
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