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Microscopically, physiologic pigmentation is characterized by the presence of increased amounts of melanin within the basal cell layer
36(11-12) 761 | DOI : 10.1055/s-2004-826160

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Additional functions include 9,10 : Balancing blood pH Facilitating the conversion of vitamin D into its active form (ie, 1,25-dihydroxycholicalciferol) Producing hormones that help control blood pressure and red blood cell production Maintaining normal blood concentrations of electrolytes (eg, potassium, sodium, phosphorus, and calcium) Kidney damage and the loss of function may gradually lead to CKD