Concomitant suppression of inappropriate glucagon secretion from alpha cells further improves glycemic control by reducing hepatic glucose production during fed states [36]
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We have recently demonstrated the presence of angiotensin receptors on colonic afferent neurons 41 and consistent with the expression of these receptors on L cells 15 and sensory nerves, including nodose ganglion neurons 42,43 , a biphasic afferent response was observed in response to administration of AngII in afferent nerve recordings from intact colonic preparations
L., & Rubio-Herrera, M
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This effect was fully suppressed by the microglial inhibitor minocycline and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580, underscoring the essential role of microglial activation and the p38 MAPK pathway [72]
