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[Are there any important limitations to consider?] Of course, and it's important to state this clearly

The frustration of weight gain during hormone therapy is a common experience, and finding a path forward requires clear, evidence-based information

These include a body mass index (BMI) of 35 kg/m or above (or 32.5 kg/m or above for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds) with at least one weight-related comorbidity, and previous unsuccessful attempts at weight loss through diet and exercise

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If you use them, choose a low-dose estrogen formulation and monitor your blood pressure and cholesterol regularly

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