Expect a short wash-out, followed by gradual dosing adjustments with monitoring for side effects like nausea or fatigue
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Yoon J, Lee DG, Song H et al (2024) Xelaglifam, a novel GPR40/FFAR1 agonist, exhibits enhanced -arrestin recruitment and sustained glycemic control for type 2 diabetes
Semaglutide is typically administered as a once-weekly injection and has been shown to be effective in improving blood sugar control, promoting weight loss, and reducing cardiovascular risks in people with type 2 diabetes
Over years of therapy, cumulative lean mass loss could become clinically significant, particularly in older adults at risk for sarcopenia