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4.2 Stimuli-responsive nanoplatforms for spatiotemporal drug release The TME of osteosarcoma exhibits distinct physicochemical features, including acidic pH, elevated glutathione levels, and hypoxia, that can be exploited for stimuli-responsive drug release (45, 59)
Funding This work was supported by grants of the Basic Science Research Program through the National Research Foundation of Korea (2018R1D1A1B07046712 to SO, 2020R1A2C1009647 to WSL and 2020R1A2C1010217 to JK)
Vitamin C is an antioxidant which scavenges free radicals in the body and protects tissues from oxidative stress [10-12,16-20]
Downstream, RFK (riboflavin kinase) is essential for converting riboflavin to FMN
These include a lack of donor sources, immune rejection reactions, surgical complications, postoperative recovery, and suboptimal outcomes
This step helps to remove the cleaning solution and prevent any potential build-up on the surface
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