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Nrgaard CH, Friedrich S, Hansen CT, Gerds T, Ballard C, Mller DV, et al

Oral, BBB-penetrant delivery: The medicinal-chemistry program characterized Dihexa as metabolically stable and orally active enough to reach the brain in animals the property that distinguished it from earlier AngIV peptides [1]

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Thus, microglial GLP-1Rs play a crucial role in the development of epilepsy

In the light of the current research, it is speculated that the maladaptive changes in the gut microbiota can influence the central nervous system and evoke depressive symptoms, and the development of depression can influence gut microbiome stability, and both of these hypotheses appear to be supported by the results of human and animal studies [100]