Thyroid concerns Animal studies identified thyroid C-cell tumours with GLP-1 receptor agonists
Some patients find that weaning off tirzepatide is harder than semaglutide due to the dual receptor mechanism
The gut-brain-skin axis, upgraded Your intestines communicate with both your neurons and your pores, using GLP-1, short-chain fatty acids, and immune messengers as their language
Cureus , doi: 10.7759/cureus.77998 (2025)
These adverse effects remain the most common reason for discontinuation of GLP-1 RAs therapy (46)
Unlike oral semaglutide, which still requires fasting administration and SNAC to enable gastric uptake, orforglipron is absorbed without specific timing restrictions, offering practical advantages for adherence