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Furthermore, plasma glucose was significantly lower in the GLP-1RA group compared with the control group during the meal test after 52 weeks, P 0.05

Additionally, its insulin-independent action makes it useful in patients with insulin resistance or beta-cell dysfunction

Ebbeling, C

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Combining semaglutide with insulin or medications that stimulate insulin release, such as sulfonylureas, increases this risk

In other words, the researchers looked at the treated group only after they were exposed to GLP-1s, when their BMIs had likely fallen lower than their pre-prescription weights, the commentary writers noted