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This leads to a form of cerebral folate deficiency (CFD) , where the brain has low levels of 5-methyltetrahydrofolate (5-MTHF) , the active folate form crucial for neurotransmitter synthesis, DNA methylation, and myelin formation

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Jatakanon A, Uasuf C, Maziak W, Lim S, Chung KF, Barnes PJ: Neutrophilic inflammation in severe persistent asthma

Glutathione protects mitochondrial membranes and DNA from free radical damage 7