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Severe deficiency, neurologic symptoms, autoimmune gastritis/pernicious anemia, major malabsorption, or poor response to oral therapy may require prescription treatment and sometimes injections

Nagar H, Piao S, Kim C-S (2018) Role of mitochondrial oxidative stress in sepsis

Many injuries heal but leave behind tissue that functions poorly

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IL-1 is a typical inflammatory mediator produced by nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing 3 (NLRP3) inflammasome, leading to myocardial hypertrophy, heart failure, and coronary atherosclerosis [85, 86]

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