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Additionally, exposure to heavy metals, such as cadmium, may also contribute to the development of ME/CFS (154)

The importance of GST A3-3 is shown by inhibiting the enzyme with drugs or by RNA interference of GST A3-3 biosynthesis, treatments which both suppress the hormone production in two steroidogenic human cell lines ( Further evidence for the physiological relevance of the GST isomerase activity derives from the coregulation of dehydrogenase and GSTA3 gene transcription in the horse ( Future Prospects The available data suggest that GSTs have a supportive function, which can prevent the overproduction of the 3-keto delta5-steroids formed by hydroxysteroid dehydrogenases and thereby prevent product inhibition