Mechanisms underlying drug-induced ototoxicity The possible mechanisms by which ototoxic agents can influence auditory function are nerve demyelination, apoptosis via caspase cascade, glutamate toxicity, ROS overload, DNA/RNA damage, inhibition of mitochondrial protein synthesis, inner ear hypo-perfusion and ion disturbance on the background of gene mutations, and increased permeability of triggered drugs (Fig
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Either of these methods can be implemented in almost any laboratory using readily available, inexpensive reagents
High sugar intake can cause spikes in blood sugar, which may lead to energy crashes and increased cravings for more sugar, ultimately sabotaging your progress
Harrison GA
Using advanced neuroimaging techniques, his team demonstrated that patients with ME/CFS have significantly depleted levels of cortical glutathione compared to healthy controls