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While rare, some individuals may experience minor digestive changes such as mild diarrhea after a B12 shot

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Initial response time also depends on: Severity of the B12 deficiency Frequency of injections Underlying health conditions Absorption and metabolism differences If youre getting your first B12 shot, your provider may start you on a more aggressive schedule, such as weekly injections until your levels are normalized

The table shows cyanocobalamin is effective and affordable, but hydroxocobalamin lasts longer

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Some doctors may even prescribe B12 injections to prevent deficiencies before they start (especially if your bloodwork's numbers are on the low side).If you suffer from anemia or a B12 deficiency, you may need B12 as a treatment