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Journal of Amino Acids, Article ID 736837
Consequently, there are no satisfactory effective medications for completely curing OA, highlighting the urgent need to explore its pathogenesis and develop effective therapeutic approaches from a clinical perspective
Additionally, cAMP and PKA phosphorylate ERK1/2, which controls genes involved in proliferative and anti-apoptotic processes, and activate several proteins, such as the mitogen activated protein kinase (MAPK) cascades [63]
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Ascorbate-derived imaging probes for hyperpolarized 13 C magnetic resonance spectroscopy and positron emission tomography have been used to study redox changes (antioxidant depletion and reactive oxygen species accumulation) in vivo
Soula, M
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