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Disruption of the intestinal mucosal barrier, alterations in the microbiota, and microbial translocation lead to systemic inflammation, further impacting the hosts immune and metabolic homeostasis [4]
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FDA approval announcement for Wegovy 7.2 mg, March 2026
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The clinical question that remains: does the added complexity of dual-hormone therapy justify the incremental weight loss over semaglutide alone
To mitigate this drawback, the pharmacological administration of GIP, primarily known for its insulinotropic and mild appetite-suppressing properties [7], is also suggested to have an anti-emetic effect, potentially allowing GIP co-agonism to increase tolerability to the GLP-1 component [8]
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