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1022,1023 Newer inhibitors such as TVB-316 and TVB-2640 have shown reduced toxicity and are currently in trials for non-small cell lung cancer, prostate cancer, and HER2-positive metastatic breast cancer (NCT 03808558, NCT 03179904, and NCT 05743621)

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Antidiabetic drugs, including intranasally administered insulin, as well as GLP-1RAs, modify the processes linking T2DM with cognitive impairment [29]

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48,49 Additional SNPs associated with BE and EAC have also been identified: rs10419226 at 19p13 in CRTC1 ( P = 3.6 10), whose aberrant activation is linked to oncogenic activity

Multi-omics reveals lactylation-driven regulatory mechanisms promoting tumor progression in oral squamous cell carcinoma