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A vial left at room temperature for extended periods may look fine but contain degraded peptide that produces inconsistent or absent effects
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Accordingly, a growing number of peptide candidates are advancing through clinical pipelines, across a variety of therapeutic areas, including metabolic, oncologic, autoimmune, inflammatory, and infectious diseases, among others (Recio et al., 2017
To separate central from peripheral mechanisms, some groups add conditioned feeding paradigms and gastric emptying assays
As research continues to evolve in this area, a better understanding of potential mechanisms and risk factors will provide a more comprehensive picture of this association
Pharm Res 41 , 19912014 (2024)
