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Conclusions Treatment with GLP-1RAs significantly decreases risk of dementia, and in preclinical studies, the GLP-1RA semaglutide has shown positive effects on neuroinflammatory, vascular, and other processes hypothesized to be involved in AD pathophysiology
SIRT1 is a histone deacetylase, which may regulate the transcriptional activity of BMAL1/CLOCK, forming a metabolic feedback loop again between the circadian clock system and metabolism ( The last pathway is that the circadian clock system controls cell metabolism by regulating the nutrient sensors Sirt1 and AMP-activated protease (AMPK) (Yang et al., 2017)
In their view, placing these peptides on the Bulks List serves the greater good better than the alternative
doi:10.3181/00379727-178-42016
