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Patho-mechanisms of impaired pulmonary endothelial barrier function in pneumococcal pneumonia and ARDS As pointed out above, efficient gas exchange in the lungs requires a functional alveolar fluid clearance (AFC) capacity by type 1 and 2 alveolar epithelial cells (AT1/2), as well as the preservation of a tight alveolar-capillary barrier

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The findings suggest that: (1) Glutathione may alleviate gill damage caused by hypoxia by inhibiting tissue oxidative damage, apoptosis, autophagy, and ER stress