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We did not restrict our study to patients who were highly adherent with their medication either, which may better reflect the utility of these medications in every day clinical practice. White and colleagues collected electronic health records and health insurance claims data from 2,405 adults aged 18 years and older receiving care at a large health care system in western Pennsylvania who were dispensed a GLP-1 receptor agonist from 2011 to 2018 (mean age, 48 years
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It can be observed that proglucagon is not expressed by a single gene, but is embedded in a larger gene, and when this large gene expresses a large peptide chain (called preprohormones), it is then cleaved by specific enzymes and post-translationally modified to finally obtain fragments with different biological activities
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