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An alternative therapy is cytokine-targeting monoclonal antibodies such as those that inhibit IL-23

As mentioned previously, increased cerebrovascular resistance at rest, whether it be related to aging or disease, is typically a negative change in cerebrovascular function and is a sign of greater flow impedanceultimately leading to reductions in CBF (Thomas et al., 2021)

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2019;2019:p5681701

Realtime PCR was performed using TaqMan Universal Master Mix II, no UNG (Applied Biosystems PN 4440041) according to the protocol, using 1.33 l of undiluted cDNA per reaction and RNAspecific Taqman hydrolysis probes