At the end of the trial, compared to the group taking sulfonylureas, participants who consistently took GLP-1 medications for the entire three-year period of the study had the most pronounced reduction in risk 18%, or roughly 4 fewer major cardiovascular events per 100 people over three years
As B12 is a water-soluble vitamin, it's generally considered safe (because any not used will be excreted via your urine), but even so you shouldn't take more than the recommended doses unless recommended to do so by your GP, as some studies have shown possible negative impacts of overdoing it
Obes Surg 2014
Pharmacy Compounding Advisory Committee Meeting Information Alliance for Pharmacy Compounding
Common community options include adding cagrilintide for satiety, adding MOTS-c for mitochondrial support, or adding a GH secretagogue (covered in the Advanced Recomp Stack) for lean mass
The most common side effects of GLP-1 analogues are nausea and vomiting, which have been attributed to delayed gastric emptying [14,15,16]