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It also seems to have prevented the down-regulation of the IGF-I receptor and possibly inhibited apoptosis

Cells were lysed in PBS/Triton X-100 (0.5%) for 60 min

suggested that TB-500 may reduce TLR-mediated inflammatory signaling within oligodendrocyte progenitor cell cultures by elevating miR-146a, a regulatory RNA molecule that may suppress downstream IRAK1 and TRAF6 activity

These interactions have important clinical ramifications

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