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Discontinuation rates due to adverse events remain low across studies (approximately 4-10%), indicating good overall tolerability
Metabolic syndrome traits increase the risk of major adverse liver outcomes in type 2 diabetes
Adverse Reactions/Side Effects The following adverse reactions are also discussed elsewhere: Hypoglycemia [see Warnings and Precautions (5.3)] Hypoglycemia Due to Medication Errors [see Warnings and Precautions (5.4)] Hypersensitivity reactions [see Warnings and Precautions (5.5)] Hypokalemia [see Warnings and Precautions (5.6)] 6.1 Clinical Trial Experience Because clinical trials are conducted under widely varying designs, the adverse reaction rates reported in one clinical trial may not be easily compared to those rates reported in another clinical trial, and may not reflect the rates actually observed in clinical practice
This is not a marginal change
Reinforcing the importance of a comprehensive approach to diabetes management encourages the patient to adhere to a balanced diet and engage in regular physical activity, which can enhance the effectiveness of oral antidiabetic agents
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