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Contact your GP if cold intolerance is severe or worsening, or if accompanied by fatigue, hair thinning, dry skin, constipation, or low mood, as these may indicate thyroid dysfunction requiring investigation
For more significant changes in hyperpigmentation or overall tone, it may take 3 to 6 months of consistent use
A patient who takes semaglutide for 4 weeks, stops for 2 weeks, then restarts still accumulates receptor downregulation over time
Monitoring of this module may include assessment of protein intake, lean mass trajectory, and related metabolic indices reflecting nitrogen balance and oxidative status
2010;(2):CD007280
doi:10.1001/jama.2020.1012
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