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In the SURPASS clinical trials, which evaluated tirzepatide in over 10,000 patients with type 2 diabetes, participants experienced average reductions in total cholesterol of approximately 5-10%, LDL-C reductions of 6-13%, and triglyceride reductions of 15-25%, depending on the dose administered

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Hydroxocobalamin can cause a harmless reddish discolouration of urine for 2448 hours following injection

Its impact compounds when paired with nutritional modifications

For weight management, 0.5 mg is part of the titration phase, with a target maintenance dose of 2.4 mg weekly

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