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Clinical signs of Plaquenil toxicity include maculopathy, retinal pigment epithelium changes, advanced retinopathy with bull's eye maculopathy characterized by a ring of parafoveal RPE depigmentation, central vision loss, decreased color vision, central scotomas, photopsia and visual field deficits

Excess inflammation is a well-known contributor to aging, as it can damage tissues and organs over time

Presented for research literature review only Strano A (2002)

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13 Moreover, we evaluated each parameter in five facial areas, including the forehead, nose, cheeks, temple, and under the eye