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These authors used the obese Otsuka Long Evans Tokushima Fatty (OLETF) rat model, in which rats become hyperphagic due to knockout of the cholecystokinin receptor, which senses cholecystokinin that is released from I cells in the small intestine and regulates food intake and satiety through neuronal feedback to the brain (159)
10.1038/s41467-019-08936-1 Nat Commun
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