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In people at genuinely high lifetime risk (familial hypercholesterolaemia, established atherosclerosis, long-standing diabetes with other adverse features) aggressive targets are more defensible
Venkatraman, G
The 2024 NICE guideline asks clinicians to tailor timing to your symptoms and review it, rather than treating one figure as fixed
Ohyashiki T, Karino T, Matsui K
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Consistent long-term use typically produces the best results
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