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New Engl J Med (2021) 384:111324
Side Effects, Tolerability, and Dose Adjustment Nausea is the most frequent side effect during dose escalation, occurring in 2540% of patients in clinical trials
They may include fillers like magnesium stearate or cellulose to hold the powder together
Diastasis recti (separation of abdominal muscles) requires specific rehabilitation before traditional core exercises
Most patients reach 510% total body weight loss by the 12-week mark, with some exceeding this threshold depending on starting BMI and lifestyle changes
How Contrave Helps With Weight Loss: Science, Effects, and Safety Contraves two active ingredients work synergistically in the brain: Naltrexone: Originally used for opioid and alcohol dependence, naltrexone blocks opioid receptors in the brain
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