there was no change in ALT non-responders
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Tamoxifen increases the levels of ceramide, JNK phosphorylation and markers of apoptosis We next determined the effects of tamoxifen on caspase-3 activation, which is known to cleave poly (ADP-ribose) polymerase (PARP) and other proteins leading to apoptosis
The pellets were resuspended in RIPA buffer and centrifuged at 14,000 g to acquire nuclear extracts
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96.3% of patients achieved more than 5% weight loss compared to 27.9% on lifestyle changes alone