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However, we suggested that the lethality induced by LCS3 in VRK2-KO PC cells is primarily dependent on inhibiting the activity of GSR rather than TXNRD1, for the following reasons
The glutathione-deficient mutant pad2-1 accumulates lower amounts of glucosinolates and is more susceptible to the insect herbivore Spodoptera littoralis
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Snyder et al., 2011
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