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A 2022 dose-response RCT (Yi et al., Geroscience) at 300/600/900 mg/day raised NAD+ dose-dependently with no safety issues at 60 days

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Optic nerve damage: Particularly in individuals with Leber's disease, a hereditary condition that causes retinal degeneration and blindness in children

PubMed Central , Experimental Eye Research , vol

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