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J.PangM

In heterogeneous tumor environments, achieving selective targeting of mutant p53 cells without damaging wild-type p53-dependent normal cells is a major challenge, mainly for the following reasons: some drugs targeting mutant p53 may also be toxic to wild-type p53 cells, and the complex tumor microenvironment may affect the efficacy of drugs

Then the drug nucleophilic group will attack the reactive form get the polar, ionizable endogenous molecule

doi: 10.1016/j.biopha.2007.05.011 115

J.SunaharaK.WagnerP.WagnerK.WallaceG

EG: Project administration, Supervision, Writing original draft, Writing review & editing, Conceptualization