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(Quality-of-life measures generally improve as obesity and its symptoms remit, although formal QoL endpoints have been reported only in a limited fashion)

This means a lower and less predictable amount of the active compound might reach systemic circulation, potentially requiring higher doses and introducing variability into research findings

But its important to avoid injecting Wegovy if it has previously been frozen

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Greenblatt MB, Tsai JN, Wein MN (2017) Bone turnover markers in the diagnosis and monitoring of metabolic bone disease

PMID: 22182839