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They don't directly target the brain-gut axis the way some IBS-specific medications do, but they support the underlying gut tissue and immune signaling
This randomized, double-blind, placebo-controlled crossover study compared placebo against L-citrulline (2g) + glutathione (200mg)
Cell Commun Signaling
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Most researchers find that meal portions naturally decrease by 20 to 30%
Chew slowly and savor your meals
Each individual dose is smaller, potentially reducing per-dose side effects
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