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Glutamine deprivation rapidly activates the PI3K/Akt pathway, which drastically reduces the expression of Claudin-1, leading to a leaky barrier

Research has also examined its potential roles in modulating gene expression associated with extracellular matrix remodelling

Pregnancy and lactation No published human reproductive or lactation safety data exists

This material is a research chemical for in-vitro laboratory use only and is not intended for human or veterinary use

This study was prior to the use of GLP-1 drugs for obesity, so these findings are applicable to people with diabetes

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