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Metformin is a popular drug used to target oxphos throughout these studies, and while it is FDA approved for management of diabetes, it is known for having many off-target effects

Functional cAMP accumulation assays confirmed full agonist activity at MC1R, MC3R, MC4R, and MC5R with EC values that correlated closely with binding affinities Dorr et al., 199600160-3)

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