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In tumor-promoting settings, it can activate oncogenic signaling (e.g., Wnt/-catenin, ILK/AKT/mTOR, MAPK), induce inflammation/oxidative stress, and enhance proliferation, angiogenesis and metastasis [174,175,176,177]

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Seminal and molecular evidence that sauna exposure affects human spermatogenesis

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GLP-1R causes a reduction in hepatic steatosis and inflammation and increases fat metabolism mediated by increasing hepatic insulin sensitivity [52,53,54]

STAT1 binds consensus sequences known as GAS motifs (interferon g amma- a ctivated s equence), to activate CD26 gene promoters