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[1] [2] B12 functions as a cofactor in cellular metabolism, participating in the conversion of homocysteine to methionine and the metabolism of methylmalonic acid, both crucial for energy production
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Metabolism , 48 , 631635
On that test, an NNMT inhibitor plus an NAD+ precursor is at least internally coherent one addresses the drain, the other the supply while pairing 5-Amino-1MQ with an unrelated appetite-acting compound is not synergy, it is simply two separate interventions being run at once